Quininae Citras. Quinine Citrate.
C46H62N4O14 = 894.536.
Quinine citrate, (C20H24N2O2)2H8C6H5O7+3H2O, may be prepared by boiling 3.086 of anhydrous quinine, or 3.6 of the crystallised alkaloid, with a solution of 1 of crystallised citric acid in 100 of water. The clear solution thus obtained is filtered, allowed to cool, and crystallised. Quinine citrate may be prepared extemporaneously by mixing 15 of quinine (hydrated) with 8 of citric acid, and slightly damping the mixture with water. Various formula, are given for this salt, but that given above agrees most closely with the citrate as found in commerce; on this basis the salt contains 72-5 per cent. of quinine. Quinine citrate occurs in the form of white, delicate acicular crystals, having only a slightly bitter taste, owing to its relative insolubility. The salt gives the thalleioquin reaction, and should respond to the other tests described under Quinina.
Soluble in water (1 in 1200), boiling water (1 in 30), alcohol (about 1 in 45), boiling alcohol (about 1 in 3), slightly soluble in chloroform.
Action and Uses.—Quinine citrate may be given in the form of effervescent granules, or in pills massed with glycerin of tragacanth, or it may be suspended in water.
Dose.—1/2 to 6 decigrams (1 to 10 grains).
- Granulae Quininae Citratis, B.P.C.—GRANULAR EFFERVESCENT QUININE CITRATE. 1 in 50.
- Dose.—4 to 8 grammes (60 to 120 grains).
The British Pharmaceutical Codex, 1911, was published by direction of the Council of the Pharmaceutical Society of Great Britain.