Colchicinae Salicylas. Colchicine Salicylate.
C29H31NO9 = 537.258.
Colchicine salicylate, C22H25NO6,C7H6O3, is a salt of a base found in colchicum. corm and seeds. It may be prepared by mixing 20 of colchicine with 7 of salicylic acid, moistening the mixture with water, and drying. It occurs as a yellow amorphous powder. Colchicine salicylate should be kept in a dark place.
Soluble in water, alcohol, or ether.
Action and Uses.—Colchicine salicylate may be administered in pills with milk sugar and glycerin of tragacanth, but is more generally dispensed in capsules containing in each 1/4 milligram (1/250 grain) of colchicine salicylate dissolved in methyl salicylate, one or two capsules being given for a dose.
Dose.—1/2 to 2 milligrams (1/120 to 1/30 grain).
The British Pharmaceutical Codex, 1911, was published by direction of the Council of the Pharmaceutical Society of Great Britain.