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Tinctura Cinchonae Composita (U. S. P.)—Compound Tincture of Cinchona.

Related entry: Cinchona wossname
SYNONYMS: Compound tincture of Peruvian bark, Huxham's tincture of bark.

Preparation.—"Red cinchona, one hundred grammes (100 Gm.) [3 ozs. av., 231 grs.]; bitter orange peel, eighty grammes (80 Gm.) [2 ozs. av., 360 grs.]; serpentaria, twenty grammes (20 Gm.) [309 grs.]; glycerin, seventy-five cubic centimeters (75 Cc.) [2 fl℥, 257♏]; alcohol, water, each, a sufficient quantity to make one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]. Mix the glycerin with eight hundred and fifty cubic centimeters (850 Cc.) [28 fl℥, 356♏] of alcohol and seventy-five cubic centimeters (75 Cc.) [2 fl℥, 257♏] of water. Having mixed the cinchona, bitter orange peel, and serpentaria, reduce them to a fine (No. 60) powder. Moisten the powder with two hundred cubic centimeters (200 Cc.) [6 fl℥, 366♏] of the menstruum, and macerate for 24 hours; then pack it firmly in a cylindrical glass percolator, and gradually pour on the remainder of the menstruum. When the liquid has disappeared from the surface, gradually pour on more of a mixture of alcohol and water, made in the same proportions as before, and continue the percolation, until one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏] of tincture are obtained"—(U. S. P.). This aromatic tincture has a deep reddish-brown color, and an astringent, bitter taste. It is liable to precipitate, like tincture of cinchona, but this is, in a measure, retarded by the glycerin present.

Action, Medical Uses, and Dosage.—This tincture is an efficient stomachic bitters, and may be used wherever a mild tonic of this character is desired. The dose is 2 or 3 fluid drachms, or more.

Related Tinctures.—TINCTURA CINCHONAE COMPOSITA, Compound tincture of Peruvian bark. The following is the old London formula modified by Prof. King: "Take of calisaya bark, in fine powder, 4 ounces; bitter orange peel, 3 ounces; Virginia snakeroot, in moderately fine powder, 6 drachms; saffron, in coarse powder, 2 drachms; cochineal, in fine powder, 1 drachm; good diluted alcohol, 20 fluid ounces, or a sufficient quantity"—(Lond.). Form it into a tincture by maceration or percolation, as explained under Tincturae, and make 20 fluid ounces of tincture. This tincture is generally known as Huxham's tincture of bark. Prof. King preferred brandy as the menstruum.

TINCTURA ANTIPERIODICA (N. F.), Antiperiodic tincture, Warburg's tincture.—I. Without aloes. Rhubarb, thirty-six grammes (36 Gm.) [1 oz. av., 118 grs.]; angelica seed, thirty-six grammes (36 Gm.) [1 oz. av., 118 grs]; elecampane, eighteen grammes (18 Gm.) [278 grs.]; saffron, eighteen grammes (18 Gm.) [278 grs.]; fennel, eighteen grammes (18 Gm.) [278 grs.]; gentian, nine grammes (9 Gm.) [139 grs.]; zedoary root, nine grammes (9 Gm.) [139 grs.]; cubeb, nine grammes (9 Gm.) [139 grs.]; myrrh, nine grammes (9 Gm.) [139 grs.]; white agaric, nine grammes (9 Gm.) [139 grs.]; camphor, nine grammes (9 Gm.) [139 grs.]; quinine sulphate, one hundred grammes (100 Gm.) [3 ozs. av., 231 grs.]; diluted alcohol (U. S. P.), a sufficient quantity to make five thousand cubic centimeters (5000 Cc.) [169 fl℥, 33♏]. Reduce the fibrous vegetable drugs to a coarse (No. 20) powder, mix this with the myrrh and camphor, previously powdered, and digest the whole, during 12 hours, in a suitable, well-covered vessel, with forty-two hundred and fifty cubic centimeters (4250 Cc.) [143 fl℥, 140♏] of diluted alcohol, on a water-bath, avoiding, as much as possible, any loss of alcohol by evaporation. Then strain off the liquid with pressure, dissolve the quinine sulphate in the strained liquid, with a gentle heat, if necessary, filter, and pass enough diluted alcohol, first through the strainer and then through the filter to make the product measure five thousand cubic centimeters (5000 Cc.) [169 fl℥, 33♏]. Each fluid ounce contains 10 grains of quinine sulphate. Note.—This preparation, made without aloes, is intended to serve as a stock tincture, from which the regular 'Warburg's Tincture' is to be made, when required. 'Warburg's Tincture without Aloes' is also often prescribed or asked for, and in this case the above preparation is to be dispensed. The original formula directed by Dr. Warburg, contained the old Confectio Damocratis as one of the ingredients. The latter is a very complex preparation, many of the constituents being unobtainable at the present day. It has, therefore, been omitted. II. With aloes.—Extract of aloes (U. S. P.), seventeen and one-half grammes (17.5 Gm.) [270 grs.]; antiperiodic tincture, without aloes, one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]. Dissolve the extract in the tincture. Note.—When 'Warburg's Tincture, without any further specification, is ordered, this preparation (containing aloes) is to be dispensed"—(Nat. Form.).


King's American Dispensatory, 1898, was written by Harvey Wickes Felter, M.D., and John Uri Lloyd, Phr. M., Ph. D.



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