Extractum Krameriae (U. S. P.)—Extract of Krameria. Extractum Krameriae Fluidum (U. S. P.)—F
Extractum Krameriae (U. S. P.)—Extract of Krameria.
Related entry: Krameria (U. S. P.)—Krameria
SYNONYM: Extract of rhatany.
Preparation.—"Krameria, in No. 40 powder, one thousand grammes (1000 Gm.) [2 lbs. av., 3 ozs., 120 grs.]; water, a sufficient quantity. Moisten the powder with three hundred cubic centimeters (300 Cc.) [10 fl℥, 69♏] of water, pack it in a conical glass percolator, and gradually pour water upon it, until the infusion passes but slightly imbued with the astringency of the krameria. Heat the liquid to the boiling point, strain, and evaporate the strained liquid, by means of a water-bath, at a temperature not exceeding 70° C. (158° F.), to dryness"—(U. S. P.).
Description, Medical Uses, and Dosage.—Good extract of rhatany is of a dark-red color, somewhat glossy, non-hygroscopic, faintly odorous, powerfully astringent, and almost wholly dissolved by water. Its evaporation should be performed quickly (or else in vacuo), as the atmosphere speedily oxidizes its active principles, impairing them, and rendering them more or less insoluble. The bark of the root furnishes the greatest amount of extract, and that prepared with water is superior to that made with alcohol. For some purposes a soft extract is prepared by stopping the evaporation at the proper time. Much of the extract of rhatany found in commerce is of an inferior quality. It does not keep well, becoming brittle and hard by age, even in close containers. Extract of rhatany may be used whenever an astringent is required; in some cases it will be found preferable to any other agent of this class. The soft extract may be advantageously used as a local application to ulcers, hemorrhoids, and fissures of the anus. The dose is from 5 to 20 grains, 3 or 4 times a day.
Extractum Krameriae Fluidum (U. S. P.)—Fluid Extract of Krameria.
SYNONYM: Fluid extract of rhatany.
Preparation.—"Krameria, in No. 30 powder, one thousand grammes (1000 Gm.) [2 lbs. av., 3 ozs., 120 grs.]; glycerin, one hundred cubic centimeters (100 Cc.) [3 fl℥, 183♏]; diluted alcohol, a sufficient quantity to make one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]. Mix the glycerin with nine hundred cubic centimeters (900 Cc.) [30 fl℥, 208♏] of diluted alcohol, and, having moistened the powder with four hundred cubic centimeters (400 Cc.) [13 fl℥, 252♏] of the mixture, pack it firmly in a cylindrical glass percolator; then add enough menstruum to saturate the powder and leave a stratum above it. When the liquid begins to drop from the percolator, close the lower orifice, and, having closely covered the percolator, macerate for 48 hours. Then allow the percolation to proceed, gradually adding, first, the remainder of the menstruum, and afterwards diluted alcohol, until the krameria is exhausted. Reserve the first seven hundred cubic centimeters (700 Cc.) [23 fl℥, 321♏] of the percolate, and evaporate the remainder to a soft extract; dissolve this in the reserved portion, and add enough diluted alcohol to make the fluid extract measure one thousand cubic centimeters (1000 Cc.) 33 fl℥, 391♏]"—(U. S. P.).
Description, Medical Uses, and Dosage.—(See Krameria). A deep brown-red, decidedly astringent fluid. It may be used where the amount of alcohol contained in the tincture is objectionable, and besides, possesses greater astringency than the latter preparation. It is prone to disintegrate, behaving like other red-tannate fluids (see Fluid Extract of Gossypium). Dose, 10 to 60 minims.
King's American Dispensatory, 1898, was written by Harvey Wickes Felter, M.D., and John Uri Lloyd, Phr. M., Ph. D.