Extractum Lupulini.—Extract of Lupulin.
Related entry: Lupulinum (U. S. P.)—Lupulin
Preparation.—Take of commercial lupulin, 4 ounces; alcohol, 8 fluid ounces. Place the lupulin loosely in a percolator, cover with alcohol, and allow it to stand an hour. Then gradually add alcohol until 2 pints of filtered liquor are obtained, or the drug is practically exhausted. Distill or evaporate off the alcohol, reducing the residue to the consistence of a soft extract. The above extract contains the medicinal principles of the lupulin unimpaired, is of uniform strength, and is in a form convenient for pills. Commercial lupulin yields about 40 grains of extract to 1 drachm of the grains.
Medical Uses and Dosage.—(See Lupulinum). This extract possesses the active properties of the hops in an eminent degree, and may be used in all cases where lupulin is admissible. The dose is from 2 to 10 grains, 3 times a day.
Extractum Lupulini Fluidum (U. S. P.)—Fluid Extract of Lupulin.
Preparation.—"Lupulin, one thousand grammes (1000 Gm.) [2 lbs. av., 3 ozs., 120 grs.] alcohol, a sufficient quantity to make one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]. Moisten the lupulin with two hundred cubic centimeters (200 Cc.) [6 fl℥, 366♏] of alcohol, and pack it firmly in a cylindrical percolator. Then add enough alcohol to saturate the lupulin and leave a stratum above it. When the liquid begins to drop from the percolator, close the lower orifice, and, having closely covered the percolator, macerate for 48 hours. Then allow the percolation to proceed, gradually adding alcohol, until the lupulin is exhausted. Reserve the first seven hundred cubic centimeters (700 Cc.) [23 fl℥, 321♏] of the percolate, and evaporate the remainder to a soft extract; dissolve this in the reserved portion, and add enough alcohol to make the fluid extract measure one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]"—(U. S. P.).
Description, Medical Uses, and Dosage.—(See Lupulinum). A dark reddish-brown fluid, possessing the taste and odor of hops. Owing to its resinous nature, it can not be mixed with aqueous preparations without the presence of some emulsifying medium. Robbins suggests that lupulin be packed unmoistened to avoid the formation of a mass which is percolated with difficulty. This fluid extract may be used wherever lupulin is indicated; 1 fluid drachm is equivalent to 1 drachm of lupulin, so the dose can be readily proportioned. It may be advantageously combined, at times, with fluid extract of scutellaria, wild cherry. or valerian, etc.
King's American Dispensatory, 1898, was written by Harvey Wickes Felter, M.D., and John Uri Lloyd, Phr. M., Ph. D.