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Extractum Spigeliae Fluidum (U. S. P.)—Fluid Extract of Spigelia. Extractum Spigeliae Fluidu

Extractum Spigeliae Fluidum (U. S. P.)—Fluid Extract of Spigelia.

Related entry: Spigelia (U. S. P.)—Spigelia

Preparation.—"Spigelia, in No. 60 powder, one thousand grammes (1000 Gm.) [2 lbs. av., 3 ozs., 120 grs.]; diluted alcohol, a sufficient quantity to make one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]. Moisten the powder with three hundred cubic centimeters (300 Cc.) [10 fl℥, 69♏] of diluted alcohol, and pack it firmly in a cylindrical percolator; then add enough diluted alcohol to saturate the powder and leave a stratum above it. When the liquid begins to drop from the percolator, close the lower orifice, and, having closely covered the percolator, macerate for 48 hours. Then allow the percolation to proceed, gradually adding diluted alcohol, until the spigelia is exhausted. Reserve the first eight hundred and fifty cubic centimeters (850 Cc.) [28 fl℥, 356♏] of the percolate, and evaporate the remainder to a soft extract; dissolve this in the reserved portion, and add enough diluted alcohol to make the fluid extract measure one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]"—(U. S. P.).

Description, Medical Uses, and Dosage.—(See Spigelia). This is a deep-brown translucent, concentrated tincture, possessing the taste of the crude drug. In the original process sugar was employed; this was supplanted, in 1870, by 50 per cent of glycerin; at the present time both have been discarded, the preparation having been found to keep well without them. This forms a fluid extract which may be employed in all cases where pink-root is indicated. The dose for an adult is from 2 to 4 fluid drachms; for a child 1 or 2 years of age, from 10 to 30 minims.

Extractum Spigeliae Fluidum Compositum.—Compound Fluid Extract of Spigelia.

SYNONYM: Fluid extract of entozoic powder.

Preparation.—Take of pink-root, swamp milkweed, mandrake, bitter-root, each, in fine powder, 21 troy ounces; balmony, in moderately fine powder, 5 troy ounces; alcohol, diluted alcohol, each, a sufficient quantity. Add a sufficient quantity of the alcohol to the powders to thoroughly moisten them, and allow the mixture to macerate for 24 hours; then transfer it to a percolator, and gradually add alcohol until 12 fluid ounces have passed, which set aside. Then gradually add diluted alcohol to the residuum in the percolator, until it is exhausted; evaporate this in a water-bath, to 4 fluid ounces, and, while warm mix in the reserved tincture, and make 1 pint of fluid extract.

Medical Uses and Dosage.—This fluid extract may be used instead of the compound powder of spigelia, in doses of from 5 to 8 drops for a child a year old, or from 10 to 20 drops for an adult, repeating the dose every hour until it acts freely upon the bowels, after which administer the dose 3 times a day, for several days in succession. A very pleasant preparation for worms may be made by adding 1 part of this fluid extract to 12 parts of simple syrup, of which the dose for a child a year old is a teaspoonful, and for an adult a tablespoonful, to be repeated in the same manner as named in the preceding doses. This will answer especially for those children who can not take the entozoic powder (J. King).

Extractum Spigeliae et Sennae Fluidum.—Fluid Extract of Spigelia and Senna.

Related entry: Senna (U. S. P.)—Senna

Preparation.—Take of coarsely-powdered pink-root, 16 ounces (av.); senna, in coarse powder, 8 ounces (av.); white sugar, 24 ounces (av.); carbonate of potassium, 1 ounce (av.); oil of caraway, oil of anise, each, 1/2 drachm; diluted alcohol, a sufficient quantity. Moisten the pink-root and senna with diluted alcohol, and macerate for 48 hours. Then introduce them into a percolator, and gradually add diluted alcohol until 5 pints have passed. Evaporate this in a water-bath to 20 fluid ounces, and add the carbonate of potassium, which prevents any resinous substance from being precipitated, and also modifies the griping action of the senna. Triturate the oils with a portion of the sugar, then with the whole of it, add this to the evaporated liquid, and dissolve the sugar by a gentle heat. The whole should measure 2 pints (W. Procter, Jr.).

This fluid extract may also be prepared by mixing together fluid extract of pink-root, 5 fluid ounces; fluid extract of senna, 3 fluid ounces, dissolving in them carbonate of potassium, 2 drachms, and oils of caraway and anise, each, 10 minims (W. Procter, Jr., Proc. Amer. Pharm. Assoc., 1859, p. 276).

Medical Uses and Dosage.—This fluid extract, which is an elegant preparation, is quite a pleasant medicine, possessing both cathartic and anthelmintic properties. An adult may take half a fluid ounce or an ordinary tablespoonful or a dose; and a child 2 to 4 years old, 1 fluid drachm or a teaspoonful.

King's American Dispensatory, 1898, was written by Harvey Wickes Felter, M.D., and John Uri Lloyd, Phr. M., Ph. D.

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