Quininae Glycerophosphas. Quinine Glycerophosphate.
C43H57N4O10P, 4H2O = 892.6.
Quinine glycerophosphate, (C20H25N2O2)2C3H5(OH)2H2PO4, 4H2O, may be prepared by decomposing a solution containing to of calcium glycerophosphate in 300 of water with a solution containing 34.8 of quinine hydrochloride in 1000 of water, washing the resulting precipitate with a little cold water, draining and drying; or by adding glycerophosphoric acid in absolute alcohol to a solution of quinine in ether, collecting the abundant white precipitate formed, and washing with more ether. This salt is also known under the trade-name Kineurine. It contains 72.64 per cent. of anhydrous quinine and 8.07 per cent. of water of crystallisation. Quinine glycerophosphate occurs in the form of fine, white, crystalline needles, or as a white, crystalline powder, which is odourless and bitter, but not so intensely bitter as quinine sulphate; it is permanent in the air. On heating to 100° it loses its water of crystallisation, and melts when anhydrous at 154°. It gives the thalleioquin reaction.
Soluble in water (about 1 in 200), boiling water (1 in 100), alcohol (1 in 40), or glycerin; easily soluble in boiling alcohol; insoluble in ether.
Action and Uses.—Quinine glycerophosphate may be administered in cachets or in capsules. It is also a constituent of various compounded medicines.
Dose.—1/2 to 6 decigrams (1 to 10 grains).
The British Pharmaceutical Codex, 1911, was published by direction of the Council of the Pharmaceutical Society of Great Britain.