Fluidextractum Hydrastis. U. S. (Br.)
Fluidextract of Hydrastis. Fldext. Hydrast. [Fluidextract of Golden Seal]
Related entries: Hydrastis
Preparations: Fluidextract of Hydrastis
"One hundred mils of Fluidextract of Hydrastis yields not less than 1.8 Gm. nor more than 2.2 Gm. of the ether-soluble alkaloids of Hydrastis." U. S." Liquid Extract of Hydrastis contains in 100 millilitres 2 grammes of hydrastine." Br.
Extractum Hydrastis Liquidum, Br.; Liquid Extract of Hydrastis; Extrait liquide de Hydrastis, Fr.; Extractum Hydrastis fluidum, P. G.; Hydrastis-Fluidextrakt; Flüssiges Hydrastisextrakt, G; Estratto di idraste liquido, It.; Extracto fluido de hidrastis, Sp.
"Hydrastis, in No. 40 powder, one thousand grammes [or 35 ounces av., 120 grains]. Prepare a Fluidextract by Type Process B, using a mixture of one hundred mils [or 3 fluidounces, 183 minims] of glycerin, six hundred mils [or 20 fluidounces, 138 minims] of alcohol and two hundred mils [or 6 fluidounces, 366 minims] of water as Menstruum I, and a mixture of two volumes of alcohol and one volume of water as Menstruum II. Reserve the first seven hundred and fifty mils [or 25 fluidounces, 173 minims] of percolate. After dissolving the soft extract in the reserve liquid, assay a portion as directed below, and, from the result thus obtained, ascertain by calculation the amount of alkaloids in the remainder of the liquid and dilute this with enough of Menstruum II to make each one hundred mils of the finished Fluidextract contain 2 Gm. of the ether-soluble alkaloids of hydrastis.
"Hydrastis Rhizome, in No. 60 powder, 1000 grammes; Alcohol (60 per cent.), a sufficient quantity. Exhaust the Hydrastis Rhizome with the Alcohol by the percolation process; reserve the first eight hundred and fifty millilitres of the percolate; recover the alcohol from the remainder by distillation; evaporate to a soft extract and dissolve in the reserved portion.
"Assay.—Proceed as directed under Fluidextractum Belladonna Radicis, modifying the process there given by using 5 mils of Fluidextract of Hydrastis instead of 10 mils of the fluidextract of belladonna root and using only ether as the immiscible, solvent throughout the assay. Dry the residue to constant weight at 100° C. (212° F.), instead of titrating it. The weight represents the amount of ether-soluble alkaloids in 5 mils of the Fluidextract of Hydrastis." U. S.
"Determine the proportion of hydrastine in the liquid extract thus obtained by the following process: Transfer 10 millilitres of the liquid extract to a 100 millilitre graduated flask, add 20 millilitres of solution of potassium iodide diluted with 60 millilitres of water, and then sufficient water to produce 100 millilitres. Shake the mixture for several minutes and filter. Transfer 50 millilitres of the filtrate to a separator, render alkaline with solution of ammonia, add 30 millilitres of ether, and shake at intervals during several minutes. Allow the liquids to separate, draw off the aqueous solution into a beaker and the ethereal solution into a tared beaker. Return the aqueous solution to the separator and repeat the operation with two successive portions, each of 20 millilitres, of ether for one minute. Draw off and reject the aqueous layer; transfer the ethereal solutions to the tared beaker and evaporate at a gentle heat; dry the residue on a water-bath and weigh. The weight is that of the hydrastine in 5 millilitres of the liquid extract examined. To the remainder of the liquid extract add sufficient of the menstruum to produce a Liquid Extract of Hydrastis containing 2 grammes of hydrastine in 100 millilitres. Examined by the foregoing process Liquid Extract of Hydrastis is found to contain in 100 millilitres 2 grammes of hydrastine. Limit of error 0.1 gramme in excess or defect. This Liquid Extract contains 2 grammes of hydrastine in 100 millilitres; 110 minims contain 2 grains." Br.
The fluidextract thoroughly represents the drug. It is of a deep brownish-yellow color.
Dose, from fifteen minims to one fluidrachm (0.9-3.75 mils).
Off. Prep.—Tinctura Hydrastis, Br.; Mistura Rhei Alkalina, N. F.