Extractum Grindeliae Fluidum (U. S. P.)—Fluid Extract of Grindelia.

Related entry: Grindelia (U. S. P.)—Grindelia

Preparation.—"Grindelia, in No. 30 powder, one thousand grammes (1000 Gm.) [2 lbs. av., 3 oz., 120 grs.]; alcohol, a sufficient quantity to make one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]. Moisten the powder with three hundred cubic centimeters (300 Cc.) [10 fl℥, 69♏] of alcohol, and pack it firmly in a cylindrical percolator; then add enough alcohol to saturate the powder and leave a stratum above it. When the liquid begins to drop from the percolator, close the lower orifice, and, having closely covered the percolator, macerate for 48 hours. Then allow the percolation to proceed, gradually adding alcohol until the grindelia is exhausted. Reserve the first eight hundred and fifty cubic centimeters (850 Cc.) [28 fl℥, 356♏] of the percolate. Distill off the alcohol from the remainder by means of a water-bath, and evaporate the residue to a soft extract; dissolve this in the reserved portion, and add enough alcohol to make the fluid extract measure one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]"—(U. S. P.).

Description, Medical Uses, and Dosage.—(See Grindelia). This well represents the virtues of grindelia, the activity of which probably depends upon its resin and essential oil, alcohol being, therefore, the proper menstruum. It is a dark brown-green fluid, having the characteristic odor of the plant, and does not mix well with water owing to the abundance of resinous material present, which separates when so treated. This fluid extract was originated by Parke, Davis & Co., of Detroit, to whom belongs the credit of its introduction. Dose, 10 to 60 minims.

King's American Dispensatory, 1898, was written by Harvey Wickes Felter, M.D., and John Uri Lloyd, Phr. M., Ph. D.