Extractum Lupulini Fluidum (U. S. P.)—Fluid Extract of Lupulin.
Preparation.—"Lupulin, one thousand grammes (1000 Gm.) [2 lbs. av., 3 ozs., 120 grs.] alcohol, a sufficient quantity to make one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]. Moisten the lupulin with two hundred cubic centimeters (200 Cc.) [6 fl℥, 366♏] of alcohol, and pack it firmly in a cylindrical percolator. Then add enough alcohol to saturate the lupulin and leave a stratum above it. When the liquid begins to drop from the percolator, close the lower orifice, and, having closely covered the percolator, macerate for 48 hours. Then allow the percolation to proceed, gradually adding alcohol, until the lupulin is exhausted. Reserve the first seven hundred cubic centimeters (700 Cc.) [23 fl℥, 321♏] of the percolate, and evaporate the remainder to a soft extract; dissolve this in the reserved portion, and add enough alcohol to make the fluid extract measure one thousand cubic centimeters (1000 Cc.) [33 fl℥, 391♏]"—(U. S. P.).
Description, Medical Uses, and Dosage.—(See Lupulinum). A dark reddish-brown fluid, possessing the taste and odor of hops. Owing to its resinous nature, it can not be mixed with aqueous preparations without the presence of some emulsifying medium. Robbins suggests that lupulin be packed unmoistened to avoid the formation of a mass which is percolated with difficulty. This fluid extract may be used wherever lupulin is indicated; 1 fluid drachm is equivalent to 1 drachm of lupulin, so the dose can be readily proportioned. It may be advantageously combined, at times, with fluid extract of scutellaria, wild cherry. or valerian, etc.