Tinctura Chloroformi et Morphinae.—Tincture of Chloroform and Morphine.

Botanical name: 

Related entries: Opium (U. S. P.)—Opium

Preparation.—"Take of chloroform, 1 fluid ounce; ether, 2 fluid drachms; rectified spirit, 1 fluid ounce; hydrochlorate of morphine, 8 grains; diluted hydrocyanic acid, ½ fluid ounce; oil of peppermint, 4 minims; liquid extract of liquorice, 1 fluid ounce; treacle, 1 fluid ounce; syrup, a sufficiency. Diffuse the hydrochlorate of morphine and oil of peppermint in the spirit, and add the chloroform and ether. Mix the liquid extract of liquorice and treacle with 3 fluid ounces of syrup, add this to the previously formed solution, mix them thoroughly, add the hydrocyanic acid, and increase the volume to 8 fluid ounces by further addition of syrup"—(Br. Pharm., 1885).

This preparation contains in a 10-minim dose, chloroform, 1 ¼ minims; ether, ⅓ minim; rectified spirit, 1 ¼ minims; morphine hydrochlorate, 1/43 grain; diluted hydrocyanic acid, ⅝ minim; oil of peppermint, 1/80 minim; and liquid extract of liquorice, 1 ¼ minims (also see Related Compounds, p. 1952 (two paragraphs down)).

Action, Medical Uses, and Dosage.—This agent is an anodyne, and may be used in various forms of colic, in cough, and delirium tremens. Dose, 10 to 60 minims.

Related Preparations.—MISTURA CHLOROFORMI ET OPII (N. F.), Mixture of chloroform and opium, Chloroform anodyne. "Purified chloroform, 2 fluid ounces; oil of peppermint, 16 minims; tincture of Indian cannabis, 2 fluid ounces; tincture of quillaja (N. F.), 2 fluid ounces; fluid extract of belladonna, 128 minims; deodorized tincture of opium, 2 ¾ fluid ounces; tincture of capsicum, 1 fluid ounce; purified extract of glycyrrhiza, 240 grains; water, ½ fluid ounce; syrup, enough to make 16 fluid ounces. Triturate the purified extract of glycyrrhiza with the water and 1 fluid ounce of the syrup until it is dissolved. Mix the fluid extract of belladonna, deodorized tincture of opium and tincture of capsicum, and add them to the solution first prepared. Then mix the chloroform, oil of peppermint, tincture of Indian cannabis, and tincture of quillaja, and add them to the mixture. Finally, add enough syrup to make 16 fluid ounces, and mix the whole thoroughly together. This mixture should be shaken whenever any of it is to be dispensed. Each fluid drachm represents 7 ½ minims of chloroform, 7 ½ minims of tincture of Indian cannabis, 3 ¾ minims of tincture of capsicum, 1 minim of fluid extract of belladonna, and about 1 grain of opium. Note.—This preparation is intended to fulfil the same purposes as the Tinctura Chloroformi et Morphinae of the British Pharmacopoeia, though the composition of the latter differs materially from that of the mixture above given"—(Nat. Form.).

TINCTURA CHLOROFORMI ET MORPHINAE COMPOSITA, Compound tincture of chloroform and morphine.—Take of "chloroform, 1 ½ fluid ounces (Imp.), or 75 cubic centimeters (Metric); morphine hydrochloride, 87 ½ grains, or 10 grammes; diluted hydrocyanic acid, 1 fluid ounce, or 50 cubic centimeters; tincture of capsicum, ½ fluid ounce, or 25 cubic centimeters; tincture of Indian hemp, 2 fluid ounces, or 100 cubic centimeters; oil of peppermint, 14 fluid ounces, or 1.5 cubic centimeters; glycerin, 5 fluid ounces, or 250 cubic centimeters; alcohol (90 per cent), a sufficient quantity. Mix the chloroform, tincture of capsicum, tincture of Indian hemp, oil of peppermint, and glycerin, with 9 fluid ounces of the alcohol, and dissolve the morphine, hydrochloride in the mixture; add the diluted hydrocyanic acid; then mix with enough of the alcohol to form 1 pint (or 1000 cubic centimeters) of the compound tincture. Dose, 5 to 15 minims. This preparation contains in a 10-minim dose, ¾ minim of chloroform, ½ minim of diluted hydrocyanic acid, and 1/11 grain of morphine hydrochloride; that is more than 4 times the proportion of morphine hydrochloride present in the corresponding preparation of the British Pharmacopoeia of 1885"—(Br. Pharm., 1898). (See also Mistura Chloroformi et Cannabis Indicae Composita (N. F.), which is also called Chloroform Anodyne.)

King's American Dispensatory, 1898, was written by Harvey Wickes Felter, M.D., and John Uri Lloyd, Phr. M., Ph. D.