Casimiroa. Casimiroa edulis La. Llav. Zapote blanco. Cochilsapote. White Sapota.—This is a large tree belonging to the Rutaceae, a native of Mexico, the leaves are employed in diarrhea and aa an anthelmintic. The seeds are said to be narcotic. In them dose Sanchez (Breve estudio Zabote blanco, Thesis, Mexico, 1893) has found a resin and a crystalline alkaloidal body. The glucoside casimirose, found in this plant by Altamirano, as well as the alkaloidal glucoside casimirin, isolated by Bikorn (A. Pharm., ccxii, p. 186), have been found by Esch and Kochmann (A. I. P. T., 1911, xxi, p. 353) to be inert. The extracts of the crude drug, however, have pronounced narcotic properties. They conclude that this drug has the extraordinary property of abolishing the sensation of pain without affecting consciousness or motility. Somewhat in contradiction to this conclusion, however, are the results of Robin and Cojon (Press. Med., 1909, p. 454) who find that the fluidextract of casimiroa in doses of one to two teaspoonfuls has hypnotic properties.