Fluidextractum Guaranae. U. S. Fluidextract of Guarana.

Botanical name: 

Fldext. Guaran.

Related entries: Guarana

"One hundred mils of Fluidextract of Guarana yields not less than 3.6 Gm. nor more than 4.4 Gm. of caffeine." U. S.

Extrait liquide de Guarana, Fr.; Flüssiges Guaranaextrakt, G.

"Guarana, in No. 60 powder, one thousand grammes [or 35 ounces av., 120 grains]. Prepare a Fluidextract by Type Process A, using a mixture of three volumes of alcohol and one volume of water as the menstruum, and reserving the first eight hundred mils [or 27 fluidounces, 24 minims] of percolate. After dissolving the soft extract in the reserve liquid, assay a portion as directed below, and, from the result thus obtained, ascertain by calculation the amount of alkaloid in the remainder of the liquid and dilute this with enough menstruum to make each one hundred mils of the finished Fluidextract contain 4 Gm. of caffeine." U. S.

"Assay.—Introduce 5 mils of Fluidextract of Guarana into a separator, add 1 mil of ammonia water, and shake out the alkaloid with chloroform until completely extracted, as shown by testing with iodine T.S. Evaporate the combined chloroform solutions to dryness and dissolve the residue in 20 mils of distilled water with the aid of heat. Allow this to cool, filter it into a separator and wash the container and filter with several small portions of distilled water, adding the rinsings to the liquid in the separator. Then shake out the alkaloid with chloroform until completely extracted, as shown by testing with iodine T.S., evaporate the combined chloroform solutions and dry the residue to constant weight at 80° C. (176° F.). The weight represents the alkaloid in 5 mils of Fluidextract of Guarana." U. S.

The menstruum for this fluidextract, U. S. P. IX (alcohol 3, water 1), is stronger than that of the U. S. P. VIII (diluted alcohol).

This fluidextract is of doubtful utility. The powdered drug itself is portable, not unpleasant to the taste, and is efficient when given suspended in water; nothing is gained by making it into a fluidextract. The fluidextract is of a deep reddish-brown color. (See Proc. A. Ph. A., 1897, 423.)

Dose, one to two fluidrachms (3.75-7.5 mils).

Off. Prep.—Elixir Guaranae, N. F.

The Dispensatory of the United States of America, 1918, was edited by Joseph P. Remington, Horatio C. Wood and others.