Periploca. Periploca graeca.
Periploca. Periploca graeca L.—From the bark of this asclepiadaceous shrub, growing in the neighborhood of the Black Sea, has been separated by Lehmann (A. Pharm., 1897, p. 157) a colorless glucoside, periplocin, C30H48O12, soluble in 125 parts of water, freely soluble in alcohol. According to the experiments of Burschinski (St.. P. M. W., 1897), it is an active cardiac poison belonging to the digitalis group. It has been used as a cardiac tonic by Cholewa (Th. M., 1904, p. 292), Silberberg (In. Dis., Odessa, 1909), and others, as a practical remedy in the treatment of heart disease. Silberberg asserts that it is better suited for intravenous injection than strophanthin. The dose is from one one-hundred-and-twentieth to one-sixtieth of a grain (0.0005-0.0011 Gm.).