Cascara Amarga. Honduras Bark.—The bark of Picramnia antidesma Sw. (Fam. Simarubaceae), a shrub growing in Jamaica, Mexico, Panama, and Columbia. It is a bitter tonic credited with specific alterative properties. For an elaborate discussion of the microscopic and chemical characters of the bark and its alkaloid picramnine, by Thompson, see A. J. P., June, 1884.