Fluidextractum Pilocarpi. U. S.

Fluidextractum Pilocarpi. U. S.

Fluidextract of Pilocarpus. Fldext. Pilocarp. [Fluidextract of Jaborandi]

Related entries: Pilocarpus
Preparations: Fluidextract of Pilocarpus

"One hundred mils of Fluidextract of Pilocarpus yields not less than 0.55 Gm. nor more than 0.65 Gm. of the alkaloids of pilocarpus." U.S.

Extractum Jaborandi Liquidum, Br., 1898: Liquid Extract of Jaborandi; Extrait liquide de Jaborandi, Fr.; Flüssiges Jaborandiextrakt, G.

"Pilocarpus, in No. 30 powder, one thousand grammes [or 35 ounces av., 120 grains]. Prepare a Fluidextract by Type Process A, using a mixture of two volumes of alcohol and one volume of water as the menstruum, and reserving the first eight hundred mils [or 27 fluidounces, 24 minims] of percolate. After dissolving the soft extract in the reserve liquid, assay a portion as directed below, and from the result thus obtained, ascertain by calculation the amount of alkaloids in the remainder of the liquid and dilute this with enough menstruum to make each one hundred mils of the finished Fluidextract contain 0.6 Gm. of the alkaloids of pilocarpus."

"Assay.—From a pipette drop 15 mils of Fluidextract of Pilocarpus evenly over the surface of 15 Gm. of purified sawdust (see Part III), and evaporate it to dryness on a water bath. Transfer the mixture to a 250 mil flask, add 150 mils of chloroform, and proceed as directed under Belladonnae Radix, fifth line of the Assay, beginning with the word 'Stopper' modifying the process there given by increasing the amount of ammonia water to 6 mils, mixed with 5 mils of distilled water, which is to be used, in divided portions, to rinse the dish in which the mixture was evaporated, the rinsings being added to the mixture in the flask; the 100 mils of chloroform solution must be drawn off from the bottom of the flask.

"Each mil of tenth-normal sulphuric acid V.S. corresponds to 20.815 milligrammes of the alkaloids of pilocarpus." U. S.

This fluidextract represents Jaborandi leaves thoroughly. Of the liquid preparations of the drug, the infusion and tincture are both open to objection, the former on account of the bulkiness of the dose, and the latter because of the amount of alcohol it contains. Liquid abstract of jaborandi was deleted from the Br. Pharm. (1914).

Dose, from fifteen minims to half a fluidrachm (0.9-1.8 mils).

The Dispensatory of the United States of America, 1918, was edited by Joseph P. Remington, Horatio C. Wood and others.