Fluidextractum Scillae. U. S.

Botanical name: 

Fluidextractum Scillae. U. S.

Fluidextract of Squill. Fldext. Scill.

Related entries: Scilla

"If assayed biologically the minimum lethal dose should not be greater than 0.0006 mil of Fluidextract, or the equivalent in Fluidextract of 0.0000005 Gm. of ouabain, for each gramme of body weight of frog." U. S.

Extrait liquide de Scille, Fr.; Flüssiges Meerzwiebelextrakt, G.

"Squill, in No. 20 powder, one thousand grammes [or 35 ounces av., 120 grains]; Diluted Alcohol, Alcohol, Water, each, a sufficient quantity, to make one. thousand mils [or 33 fluid-ounces, 6 ½ fluidrachms]. Mix two thousand mils [or 67 fluidounces, 301 minims] of alcohol with one thousand mils [or 33 fluidounces, 6 ½ fluidrachms] of water, moisten the squill thoroughly with sufficient of the mixture and allow it to macerate for two hours in a tightly-covered container. Then transfer it to a percolator, shake

it down evenly without packing, and pour on enough of the menstruum to saturate the powder and leave a stratum above it. When the liquid begins to drop from the percolator, close the lower orifice, and, having closely covered the percolator, macerate for forty-eight hours. Then allow the percolation to proceed slowly, gradually adding more menstruum composed of two volumes of alcohol and one volume of water. When the percolate measures one thousand mils [or 33 fluidounces, 6½ fluidrachms] close the lower orifice and macerate the drug twelve hours before continuing the percolation. Then collect a second one thousand mils [or 33 fluidounces, 6½ fluidrachms of percolate, again interrupt the percolation, macerate for twelve hours and then continue the percolation until the total percolate measures five thousand mils [or 169 fluid-ounces, 33 minims]. Recover the alcohol from the percolate at as low a temperature as possible and then concentrate the residue to a volume measuring eight hundred mils [or 27 fluidounces, 24 minims]. When the residue is cold, add slowly, with continuous agitation, two thousand mils [or 67 fluidounces, 301 minims] of alcohol and set the mixture aside in a tightly-stoppered container for twelve hours. Decant the supernatant liquid from the syrupy layer, filter the decanted liquid and wash the syrupy residue with two portions of three hundred mils [or 10 fluidounces, 69 minims] each of a mixture of four volumes of alcohol and one volume of water, passing the washings through the filter Into the previously collected alcoholic liquid. Reduce the combined alcoholic liquids to eight hundred mils [or 27 fluidounces, 24 minims] by distillation and finally add enough diluted alcohol to make the finished Fluidextract measure one thousand mils [or 33 fluidounces, 6 ½ fluidrachms]." U. 8.

The U. S. P. has very properly returned to an alcoholic instead of an acetic acid menstruum for this preparation, as Houghton has shown that the fluidextract of the U. S. P. VIII did not represent the activity of squills, but it is doubtful whether the complicated process of the U. S. P. IX will be employed for such a rarely used fluidextract.

Dose, from one to three minims (0.06-0.2 mil).

Off. Prep.—Syrupus Scillae Compositus, U. S., Mistura Pectoralis, Stokes, N. F.

The Dispensatory of the United States of America, 1918, was edited by Joseph P. Remington, Horatio C. Wood and others.