I have recently had an experience with a very intractable case of gleet, in which the discharge had resisted all ordinary methods of treatment for months. There was considerable tenderness in spots up and down the urethra. I cured the condition completely, by advising the patient first to evacuate the bladder, then to fill the bladder with a solution of bichloride, 1 grain in from 20 to 24 ounces of water at the body temperature, passing through the urethra, after removal of the catheter, as much as could be introduced into the bladder through a soft catheter. This was done at first every second day; later every third day, and during the last month very four or six days. A small quantity of gelsemium and macrotys was given at first to overcome the irritation, and later an infusion of marshmallows for its soothing influence.